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Best Weight Loss Pills of 2023 – Which One is Right for You?

Losing weight is a perennial challenge for most people.

Presented by Originated Media January 4, 2023

Losing weight is a perennial challenge for most people. It’s almost a cosmic practical joke that the most delicious things on Earth are the most fattening and bad for you, making the process of fighting against weight gain a daily struggle. Weight loss fads, fitness trends and even the “nuclear option” of weight loss surgery are all options, but few are appealing. So, where is a normal, regular, everyday person to turn for help? 

The key to losing weight may lie below in our list of the best weight loss pills. There was a lot of competition to make this list, but our review panel applied stringent parameters to ensure that what follows are the top five most effective weight loss pills beyond the shadow of a doubt. We read the reports, scoured the websites, compared brands side-by-side, consulted the reviews, and we can say confidently that the following list contains the best weight loss pills on the market today.

Top 5 Best Weight Loss Pills

1. PhenQ - Best Overall Weight Loss Pill

2. Trimtone - Best Fat Burning Formula for Women

3. Instant Knockout - Weight Fighting Powerhouse

4. Zotrim - Research-Backed Rockstar

5. PhenGold - Multi-Action Success

Reviews & Analysis of the Best Weight Loss Pills

1. PhenQ - Best Overall Weight Loss Pill


  • Targets 5 metabolic health areas
  • Nearly 200,000 satisfied customers
  • Patented α-Lacys reset ingredient


  • Stock limited to five per household

How It Helps You Lose Weight

PhenQ is a powerful weight loss system combining the power of its patented α-Lacys reset ingredient with a formula targeting five areas of metabolic health. This effective fusion of approaches means this best weight loss pill works harder at motivating your body to burn excess fat and lose weight more consistently. Each bottle contains a month’s supply of 60 capsules to be taken twice daily.

The α-Lacys reset element is a synthesis of cysteine and Alpha lipoic acid (also known as ALA), which regulates both oxidation and reduction of cells undergoing stress states, such as when the body is exercising. The α-Lacys reset ingredient regulates the glutamatergic system, and its cysteine and alpha lipoic acid makeup means these diet pills power your metabolism, thus burning fat more effectively. 

In essence, PhenQ is an effective weight loss pill because it boosts the systems of your body that naturally help you lose weight. It does this by stimulating your metabolism, reducing stress at the cellular level, and guarding against oxidation. The strong antioxidant properties of PhenQ’s weight loss supplements cannot be dismissed either, as they not only aid in weight loss but also help the body avoid conditions as serious as heart disease, Parkinson’s, immune system deficiencies, respiratory diseases, and even cancer. 

One of the reasons the PhenQ formula is so valuable to those looking to lose weight effectively is that the same elements that can contribute to this process can also detract from it when used in the wrong dosages or ineffectually. 

It’s not enough to simply consume α-Lacys reset. It must be made a part of a larger effort, which PhenQ accomplishes not only with the scientific dosage formula but also by pairing it with magnesium and capsimax powder. Capsimax is derived from red chili peppers. It burns calories, breaks fat down, and suppresses appetite. 

Pricing & Discounts

Get 10 percent off PhenQ weight loss supplements and free shipping with promo code FIRST10 or enjoy PhenQ’s buy two, get one free or buy three, get two free deals.

Why It’s On This List

All in all, you can see why PhenQ tops our list of the best weight loss pills. Fat burning, craving crushing, mood-boosting, and fat busting make PhenQ a five-way super slasher of weight and, when paired with solid discounts and a 60-day guarantee including a full refund, it can’t be beaten for losing weight. 

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2. Trimtone - Best Fat Burning Formula for Women


  • Specially formulated weight loss solution for female physiology
  • 100 percent natural diet pills
  • Faff-free usage


  • Shipping is free on all but the lowest single-month supply

How It Helps You Lose Weight

Full of natural ingredients proven to promote weight loss, Trimtone is a top-notch producer of results. Women of every body type benefit from the passive metabolic boost that Trimtone stimulates in the female physiology. The Trimtone team prides itself on providing a leading solution among natural weight loss pills with a strong formula of all-natural ingredients. 

Caffeine is a chief ingredient in Trimtone, as it encourages natural thermogenesis, or the burning of calories, and lipolysis, which breaks fat down. And the energy boost that caffeine is known for is a further positive for those looking to lose even more weight through motion and energy. 

The beans of green coffee further round out the caffeine profile while adding chlorogenic acid. This acid is believed to be a metabolism booster that also blocks and reduces the amounts of glucose (sugar) that try to enter your system. Green tea is another key ingredient in this Trimtone weight loss pill and is believed to help reduce carbohydrate absorption, so the body spends less time storing fat from carbs.

Grains of Paradise is another key ingredient. It helps this weight loss supplement activate brown adipose tissue, which is important to burn calories and regulate energy levels all day long. This has the further effect of reducing food cravings. Finally, Trimtone contains glucomannan, a dietary fiber that helps women feel full without feeling bloated. 

Trimtone weight weight loss supplements are known for their “faff-free” ease of use: a single dose once per day is all it takes to get going on a weight loss journey, and users of the product report seeing results within a few weeks. Each bottle contains 30 capsules, and the dosage is simply one weight loss pill every morning with water before breakfast for a full month of supply per bottle. 

Pricing & Discounts

New customers can enjoy 20 percent off their purchase with promo code TRYME20. Weight loss supplement seekers can also earn a free month of dosage with a two-month supply purchase or two free months by purchasing three. There are price breaks for each multi-month order and free shipping for two months or more. 

Why It’s On This List

Trimtone is among our top picks due to its specialty in women’s weight loss. The fact that it is made from all-natural ingredients and is backed by so much science (see the website for deep source-citing of clinical references) pushed it high onto our list of the best weight loss pills available on the market today.

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3. Instant Knockout - Weight Fighting Powerhouse


  • Weight loss supplements of choice for MMA fighters and boxers
  • Same-day shipping
  • 9 weight-dropping natural ingredients


  • Contains stimulants, so users should be aware of combinations with other stimulants

How It Helps You Lose Weight

Most people want to lose weight for personal reasons: to look better in a swimsuit, to impress someone special, or to simply feel better overall physically. But Instant Knockout was originally made for professional fighters—those for whom every ounce of excess body fat is a disadvantage in physical combat and can be the difference between winning or losing a paycheck in the ring. 

With that much on the line, the pros need a weight loss pill that will help them maintain their ideal body weight by removing excess fat from the equation. That’s where Instant Knockout comes in. Instant Knockout helps you lose weight by increasing your metabolic rate, cutting hunger cravings, and boosting your energy levels. This triple-threat combo is at the root of Instant Knockout’s effectiveness.

Instant Knockout’s weight loss powers come from nine effective body fat-reducing ingredients: green tea extract, cayenne pepper seeds, black pepper extract, caffeine, glucomannan, L-Theanine, and vitamins D3, B6, and B12. 

Green tea extract leads the charge on boosting metabolism through thermogenesis. We’ve mentioned that term before because it’s central to many of these best weight loss pills. Green tea extract promotes the body’s process of burning calories through heat by 15 percent while also amping up your energy levels.

Vitamin D3 in this best weight loss pill lowers your blood pressure, giving your body the space it needs to boost performance safely. Vitamin B6 increases dopamine which promotes focus and energy, as well as improves your mood through serotonin increases. Vitamin B12 regulates your metabolic rate and increases the efficiency of your body’s energy production from food. It also increases energy, mood, and focus. Together, these vitamins pack a punch befitting an MMA fighter!

Instant Knockout also peppers in some cayenne and black pepper extract, and you’ll find these spicy ingredients pack quite the punch of their own. Capsaicin is a fat-burning thermogenic bioactive ingredient with the power to amp up metabolism and act as the catalyst for the oxidation of fat at a higher rate and more effectively. Black pepper extract is another metabolic rate-boosting bioactive, but it has the added bonus of reducing the formation of fat cells in your body while promoting fat burning (and weight loss) through heat. 

Caffeine continues to be one of the greatest blessings to mankind, not only as a key everyday element in our morning coffee (for you coffee drinkers out there) but as a key energy-boosting element in Instant Knockout weight loss supplements. Caffeine plays the expected role of boosting energy but also aids in increased focus and weight loss by further promoting thermogenesis.

If there’s a downside to caffeine, it may be the “comedown” of energy levels after a while. That’s where the combination of caffeine with L-Theanine comes into clutch play. L-Theanine evens out the energy-boosting effects and keeps the motion and energy going at a longer, more balanced rate all day long.

The final ingredient in these best weight loss pills is glucomannan, which suppresses your food cravings and makes you feel full for longer periods of time due to its natural abilities as a dietary fiber. Glucomannan may also help with metabolism and is a key player in terms of guarding against snacking to help you keep the weight off. 

Pricing & Discounts

Save 10 percent by subscribing to recurring deliveries and get a free month when buying three months’ worth of supplies. 

Why It’s On This List

Instant Knockout Cut is on this list of best weight loss pills due to its sheer powerhouse approach to weight loss. It has a long track record of trust by professionals whose weight is a key element in their careers and income, and our review team felt that this is a high note of confidence towards its effectiveness. 

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4. Zotrim - Research-Backed Rockstar


  • Better than prescription weight loss drugs
  • Clinically proven solution to lose weight
  • Effective even without specialty diets or exercise


  • Not for women who are pregnant or breastfeeding, and those with diabetes may want to consult their doctor before use

How It Helps You Lose Weight

Zotrim is the clinically proven rockstar on our list of the best weight loss supplements available today. Backed by multiple clinical trials, this proven method to reduce appetite helps you lose weight the old-fashioned way: by simply eating less. In fact, one of these clinical studies found that Zotrim users: 

  • Consumed fewer calories (an average of 112 less)
  • Ate fewer fatty foods overall 
  • Stopped eating three minutes sooner than others

These are impressive results, and this is only from one of the five clinical trials behind Zotrim. 

Two to three of their weight loss pills before meals are the key to success with Zotrim. And while this may seem like more effort than some of the once-per-day options on this list, the results seem to speak for themselves. The company makes this practice convenient by providing a slim, travel-size case that’s easy to keep handy wherever life takes you. 

Yerba maté is a key appetite-suppressing ingredient in Zotrim. This natural herb increases energy while lowering the effects of fatigue while also injecting a great dose of antioxidants. Guarana seed is the source of caffeine in Zotrim and stimulates your metabolism and fat-burning effects. Damiana is especially helpful for those who find themselves eating to balance low mood swings, as it is a natural mood enhancer. Paired with guarana and yerba maté, however, it truly shines.

The formula for these best weight loss supplements is rounded out by vitamins B3 and B6, along with added caffeine. The vitamins burn more food calories and even out metabolic rates while boosting them and reducing the fatigue one may feel from reducing calorie intake.

Pricing & Discounts

Use code SALE20 for 20 percent off your order. 

Why It’s On This List

It’s hard to find more solid proof of effectiveness in weight loss supplements than the multiple clinical studies backing Zotrim. It’s on our list due to its natural formula and the rave reviews of the brand’s fans, but this company really did its homework, and it shows. Beyond that, any product backed by a 100-day guarantee is one that is truly confident in its ability to help people succeed in their weight loss journey. 

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5. PhenGold - Multi-Action Success


  • Five-part approach to weight loss
  • Clinically proven effectiveness
  • 3,000+ 5-star reviews


  • Dosage is three capsules, which may be challenging for those who have issues swallowing pills

How It Helps You Lose Weight

PhenGold is described as a multi-action formula for weight loss due to its five-part approach to fat burning and weight loss. The PhenGold formula is clinically proven to be effective and help you lose weight and keep it off. The five-part PhenGold approach consists of: 

  1. Fast fat burn

  2. Metabolic boosting

  3. Curbed cravings

  4. Increased energy

  5. Mood lifts

1. Fast fat burn: PhenGold activates thermogenic responses in the body to burn off fat through hormones that break down fat cells. Cayenne pepper, L-tyrosine, green tea, rhodiola, and caffeine all play roles in this process. 

2. Metabolic boosting: The PhenGold approach amps up your metabolism through caffeine and the capsaicin in cayenne pepper and green tea extract. Vitamin B6 further supports metabolism by effectively converting carbs and proteins from food consumption into energy instead of fat while also increasing the presence of L-carnitine, a fat-burning amino acid produced in the body.

3. Curbed cravings: Caffeine and capsaicin tag-team the appetite suppressing effects in PhenGold, helping you feel fuller and maintain that feeling for longer periods of time. These also combine to reduce cravings and help you control the impulse to reach for food between meals. 

4. Increased energy: PhenGold boosts both physical and mental energy all day long. It does so through caffeine, green tea, green coffee, and vitamins B12, B6, and B3, all of which pair well with rhodiola rosea to increase focus and concentration while reducing fatigue. 

5. Mood lifts: When your body gets fewer calories than you’re accustomed to, you can suffer from less than happy feelings. PhenGold counters this mood valley by including L-tyrosine, caffeine, L-theanine, B vitamins, and dimethylaminoethanol (or DMAE). Instead of feeling sad because you’re consuming less food, you can instead maintain more normal feelings and have a greater capacity for positivity and natural happiness hormones. 

Pricing & Discounts

Get a free month’s supply when buying two months’ worth of the PhenGold diet pills, or two free months with a three-month purchase. 

Why It’s On This List

PhenGold makes our list of the best weight loss pills available due to the effectiveness of its multi-action formula’s five-part approach. 

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How We Made this List of the Best Weight Loss Pills

This list of the best weight loss pills available today is the product of extensive research into the various products and companies in the weight loss supplements and weight loss pills category.

Selected brands were subject to review against a rigorous slate of criteria examining everything from ingredients to formulations. Source materials, manufacturing standards, testing, and clinical research were all considered, as were customer reviews and the length of time available on the market before any brand could make this list. 

In the end, this list consists of the best of the best options for natural weight loss pills available to consumers today. 

What to Look for When Choosing Best Weight Loss Pills

There are many weight loss pills available on the market, so it can be difficult to choose which one is the best for you. However, there are some features that you should look for when choosing the right weight loss pill for you. 

The first thing to consider is how quickly the weight loss pills work and how much they help with suppressing appetite. The next consideration would be if the ingredients found in a particular pill have any side effects or not. Lastly, another factor to consider would be if there are any extra benefits that come with taking the specific diet pills, such as increased energy levels or improved moods. 

Other features to consider when choosing a weight loss pill:

  • A weight loss pill shouldn't contain any fillers, artificial colors, or flavors.

  • It should be made with natural ingredients and should contain as few preservatives as possible.

  • It should have clinically proven ingredients that are backed by research.

  • It should have a money-back guarantee if it doesn't work for you as expected.

How Do Weight Loss Pills Work?

Weight loss pills are a type of drug used to help people lose weight. Most weight loss pills come in the form of a capsule or tablet, and you take them on a regular basis, typically one or two times per day. A weight loss pill works by increasing the body's metabolism or suppressing appetite. Even the best weight loss pills are not necessarily a magic solution that will make you lose weight overnight without any effort on your part. In fact, that would be unhealthy for your body and your mind. 

There are two types of weight loss pills: prescription and over-the-counter (OTC). Prescription weight loss drugs can be obtained from your doctor, while OTC weight loss pills can be purchased without a prescription at the pharmacy or grocery store. 

A prescription weight loss drug is usually obtained via a doctor appointment and subsequent issuing of a prescription to be filled at and picked up from a pharmacy. The amount of pills you're prescribed is usually determined by your weight, and medical conditions may play a role in their ability to help you lose weight. 

Over-the-counter weight loss supplements, often called diet pills, are different from prescription weight loss pills in that they tend to include more natural ingredients and less synthetic formulas created solely in laboratory environments. 

Despite the type, weight loss pills work in different ways, depending on the individual and their needs. These supplements may increase metabolism or suppress appetite, helping people eat less and burn more calories, which in turn helps them shed pounds and achieve weight loss goals faster.  

Some diet pills target a person's thyroid, which the body uses to regulate metabolism. Others may block the release of ghrelin (the hormone that makes people feel hungry) or prevent the absorption of fat. 

Suppressing appetite is a key effect of many of the best weight loss supplements. This effect limits the intake of calories from food by simply making you want less food and eat less of what you obtain. Another way that diet pills achieve this effect is by extending feelings of fullness in the body. Together, these effects make you want less food less often. You can see how this would contribute clearly and effectively to weight loss. 

Weight loss pills also work by triggering the release of certain hormones that can suppress your appetite and increase your metabolism. The science behind effective diet pills is complex, but there are several key points to keep in mind: 

  • Weight loss supplements may not work if you don't eat well and exercise regularly. 

  • Weight loss pills are not a replacement for a balanced, healthy diet and lifestyle.

  • There are different types of weight loss pills for different purposes.  

  • Weight loss pills cannot produce weight loss on their own in most cases. 

  • Diet pills should be used in combination with a healthy diet and lifestyle to maximize weight loss in terms of positive outcomes at a healthy rate of loss.

  • It is important to consult with your doctor when considering weight loss pills, as each person’s physiology is different, and your physician may have insights that are relevant to your specific needs.

How Long Does it Take To See Results From Weight Loss Pills?

Diet pills are not a magic solution. It takes time to see results from taking these weight loss supplements, but the answer to how long depends on a lot of factors. 

The time it takes to see results from a weight loss pill varies depending on the person, their diet and exercise habits, and their metabolism. It is important to remember that even the best weight loss pills are not an immediate solution that will make you lose all your weight overnight. It is important to be patient and not give up on your weight loss goals and the rituals and habits you form in order to ensure you are taking the diet pills regularly for maximum effectiveness.

The timing for weight loss pills varies depending on the individual, but it usually takes at least a few weeks to see any changes in weight. For some people, it can take up to six months or longer before they notice any significant difference in their weight. Typically, it is safe to plan for three-to-four months' time for most people to see results from weight loss pills. 

Are There Any Side Effects?

Weight loss pills are a popular choice for people who want to lose weight. But like almost any supplement, diet pills can also have side effects. Some of the side effects that you might experience from taking weight loss pills include:

  • Headaches

  • Nausea

  • Stomach cramps

  • Dizziness

  • Constipation

  • Dry mouth

  • Irregular heartbeat

In addition, one of the most common side effects of effective weight loss pills is that they suppress your appetite. While this is generally a positive effect (as it helps you consume fewer calories), for some people, this can also cause headaches, nausea, dizziness, and other problems such as constipation.

Note that weight loss pill products are generally not viewed as a long-term solution to weight loss and are often best used as a temporary solution for losing weight in tandem with a healthy diet, regular physical activity, and the advice of your physician.

Glossary of Weight Loss Pill Terminology

Appetite Suppressant

Appetite suppressants can be classified as drugs or dietary supplements. There are a number of different types of drugs that can be used to suppress appetite, including antidepressants and antipsychotics. The most common type of drugs are amphetamines, which are also known as "speed." These drugs are used to treat obesity, but they have been linked to addiction and abuse. Dietary supplements such as hoodia, chromium picolinate, and chitosan have also been shown to reduce appetite.

Body Mass Index (BMI)

Body Mass Index (BMI) is a number calculated from a person's weight and height. It is used to help people understand if their weight is healthy.

The Body Mass Index can be used to estimate whether someone has an appropriate level of body fat for their height. It does not measure the percentage of body fat or muscle mass, nor does it take into account age, gender, ethnicity, or other factors that may complicate the interpretation of BMI results. 

It is used as a proxy for body fat mass and obesity, although BMI does not actually measure the percentage of body fat or lean tissue.

The term "BMI" is sometimes used in place of terms like "body mass index" or "weight-to-height ratio". The higher your BMI, the more likely you are to have health problems related to being overweight or obese.

The BMI formula uses height in meters squared, divided by body weight in kilograms squared. 


Calories are units of energy in food. Calories are a unit of energy that measures the amount of energy produced by burning food. The calorie content is measured as the amount of energy needed to increase the temperature of 1 kg of water by 1 degree Celsius. 

The word "calorie" comes from the Latin calor, meaning heat. In other words, calories are units of heat transfer. The term calorie is used as a unit of energy in nutrition and science, often in the context of diet plans. 

Once your body digests and absorbs food, it turns into energy. The type of calories you consume will determine the type of energy used to power your body. For example, fats are broken down into molecules called fatty acids to create a source for electron carriers called adenosine triphosphate (ATP), which is then used by cells to make energy. 

There are many different types of calories, and they each have a different function. Usually, there are three types: protein, carbohydrate, and fat. 


Carbohydrates are the body’s primary source of energy, and they provide 4 calories per gram. They come from foods such as bread, cereals, rice, pasta, fruits, and vegetables. Carbohydrates are also the body’s main source of quick energy.


Fat is a type of lipid that is stored in the body. It can be either saturated or unsaturated, depending on what type of fatty acid it contains. 


Fiber is a type of carbohydrate found in plants. It helps prevent constipation and lowers the risk for heart disease and diabetes. Dietary fiber is needed for healthy digestion and bowel function. It also helps prevent heart disease, diabetes, and obesity because it slows the rate of food leaving your stomach.


Proteins are the building blocks of your body, and they make up 20% of human body weight. They are primarily made up of amino acids, which are what we need to create new proteins, and which provide energy to the body. Protein can be found in meat, poultry, fish and seafood, eggs, milk, and dairy products such as cheese or yogurt. Protein is essential for tissue growth, brain health, skin recovery, and muscle contractions. Proteins also help regulate blood sugar levels, may decrease appetite, and aid in the fight against weight gain. 


A serving size of food is the amount that most people typically eat in one sitting. For example, a serving size of fruit juice would be 120 milliliters (mL) or 4 fluid ounces (fl oz). A serving size of candy may be 1/3 to 1/2 cup or about 110 grams. A serving size of a cooked vegetable side could be 1/2 cup or 120 milliliters. Serving sizes for fruits and vegetables are about 3/5 of a cup or about 100 grams.


Vitamins are a type of substance that is needed by the body in small amounts to perform necessary functions. Vitamins help keep eyes, skin, and hair healthy and also promote feelings of well-being while also helping the body process food. Examples of vitamins include: 

  • Vitamin A is a fat-soluble vitamin that helps keep eyes healthy.

  • Vitamin D helps the body absorb calcium and phosphorus, which is important for bones, teeth, and muscle development. 

  • Vitamin E protects cells from damage caused by free radicals. It also has antioxidant properties that are necessary for maintaining healthy skin, hair, and nails.

  • Vitamin B1 is important for energy production and aiding in the process of converting food into energy. 

  • Vitamin B2 helps maintain cell membranes and supports intellectual function. 


We researched this list of the best weight loss pills in order to parse through the vast torrent of data out there and present a simple, easy-to-read source of reference material. This list aims to reduce the time it takes to consider the best weight loss solution for you. Whichever weight loss pills you choose, best of luck on your weight loss journey!