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LDN: Proving Beneficial for Long-COVID and Autoimmune Conditions

Low Dose Naltrexone is usually given in doses ranging from 0.001mg – 16mg, that can be easily adjusted to fit each patient's specific needs.

Presented by Sarasota Compounding Pharmacy November 2, 2022

Naltrexone is an opioid antagonist, meaning that it blocks opioid receptors. Taken at high doses of 50mg to 100mg, it’s been used for decades to help patients addicted to opiates and/or heroine fight their addiction by blocking the “high” feeling within the brain. Additionally, Naltrexone increases endorphins, which are known to enhance immunity. How does this mechanism work? By blocking opioid receptors, the brain receives a signal that endorphins are low and begins to increase endorphin production.

Years ago, a New York physician, Dr. Bernard Bihari, discovered that low doses of Naltrexone were so effective at increasing endorphins that he began researching it to fight infections, cancer, and autoimmune disorders.

Individuals with cancer, immune deficiencies, and other infections usually have lower endorphin levels. Along with endorphins, cytokines are also thought to be better modulated with low dose naltrexone therapy.

Cytokines are immune system proteins, but when in overdrive, they begin to attack the body’s own tissue. This is why many people with autoimmunity have a difficult time fighting infections.  Specific cytokines have autocrine, paracrine, and/or endocrine activity and, through receptor binding, can elicit a variety of responses, depending upon the cytokine and the target cell. Among the many functions of cytokines is the control of cell proliferation and differentiation and the regulation of angiogenesis and immune and inflammatory responses.

Low Dose Naltrexone is also thought to tamp down inflammation systemically. If left untreated, the inflammatory response can be detrimental throughout the entire body. If you are prescribed LDN, the additional benefit is that it will contribute to less inflammation. However, you will still need to address what underlying causes are contributing to your disorder, such as leaky gut.

Naltrexone has anti-inflammatory properties and has been used at low doses for years to treat conditions such as fibromyalgia, Crohn's disease and multiple sclerosis, said Dr. Jarred Younger, director of the Neuro-inflammation, Pain and Fatigue Laboratory at the University of Alabama at Birmingham.

'HUMAN AGAIN' Dr. Jack Lambert, an infectious disease expert at University College Dublin School of Medicine, had used LDN to treat pain and fatigue associated with chronic Lyme disease. During the pandemic, Lambert recommended LDN to colleagues treating patients with lingering symptoms after bouts of COVID. It worked so well that he ran a pilot study among 38 long COVID patients. They reported improvements in energy, pain, concentration, insomnia and overall recovery from COVID-19 after two months, according to findings published in July.

Nichols, a patient who was prescribed LDN for her long covid can now work all day without breaks and have a social life at home. "It has made me feel like a human again."

Unlike treatments aimed at addressing specific symptoms caused by COVID damage to organs, such as the lungs, low-dose naltrexone (LDN) may reverse some of the underlying pathology driving symptoms, a RECOVER representative said.

Low Dose Naltrexone is usually given in doses ranging from 0.001mg – 16mg, and it is a pure antagonist. Typical dosing is 4.5mg, but with compounded LDN, that can be easily adjusted to fit each patient's specific needs.

Compounded Low Dose Naltrexone (LDN): Proving Beneficial for the Following:

  • Depression
  • Hashimoto’s
  • Crohn’s Disease
  • Fibromyalgia
  • Rheumatoid Arthritis
  • Lupus
  • Lyme Disease
  • Epstein Barr Virus
  • Cancer
  • Cardiac Issues
  • Chronic Pain
  • Sjögren's syndrome
  • And many more conditions

LDN is proving to be beneficial for multiple disorders. As mentioned, compounded LDN can be precisely created and dosed specifically for you and must be purchased through a compounding pharmacy.

Why is this important?

Compounding combines an ageless art with the latest medical knowledge and state-of-the-art technology, allowing specially trained professionals to prepare customized medications to meet each patient’s specific needs. Compounding is fundamental to the profession of pharmacy and was a standard means of providing prescription medications before drugs began to be produced in mass quantities by pharmaceutical manufacturers. The demand for professional compounding has increased as healthcare professionals, patients realize that the limited number of strengths and dosage forms that are commercially available are unable to meet the unique needs of many patients. These patients may have a better response to a customized dosage form that is “just what the doctor ordered.”

Compounding Benefits:

  • Create Pure Drugs-no fillers or additives
  • Unique dosages
  • Combining drugs together
  • Various forms: tablet, capsule, liquid, etc.
  • Personalized Care

Customizing Medications

Sarasota Compounding Pharmacy is an independent, family-owned pharmacy serving the Sarasota community for over 40 years. Their compounding pharmacists work with veterinarians, pediatricians, dentists, dermatologists, and other health care professionals to prepare patient-specific medications. They specialize in meeting patient needs through innovative compounding formulations.

Sarasota Compounding Pharmacy
2075 Siesta Dr, Sarasota, FL 34239
(941) 366-0880